gvSIG is an easy to use Java desktop GIS. It has a friendly interface, and can access some popular formats (e.g. SHP, DGN, DXF, DWG, TIFF, JPEG, ECW, SID, etc). It will integrate in a single view both local vector and raster data, as well as remote data through WMS or WCS. It allows layout design for printing. It is meant for end-users of geographical information, and currently has Spanish, Valencian, English, and 6 more interfaces. It's designed to be easily extended.
